IL-4 and TGF-β Regulate Inflammatory cytokines and Cellular Infiltration in the Lung in Mouse-adapted SARS-CoV-2 Infection
Solomon Taye Sima, Lucinda Puebla-Clark, María González-Orozco, Mark Joseph Endrino, Thomas R. Shelite, Tseng Hsiang-Chi, Yazmin B. Martinez-Martinez, Matthew B. Huante, Hannah G. Federman, Komi Gbédandé, Vineet D. Menachery, Mark C. Siracusa, Mark A. Endsley, Sara M. Dann, Janice Jones Endsley, , Robin Stephens
This study investigates how IL-4 and TGF-β regulate inflammation and immune cell infiltration in mouse-adapted SARS-CoV-2 infection, finding that neutralizing these cytokines alters disease pathology.
bioRxiv · May 13, 2025 · PreprintImmunology