Janice Jones Endsley

Sirtuin2 blockade inhibits replication of Human Immunodeficiency Virus-1 and 1 Mycobacterium tuberculosis in macrophages and humanized mice

This study shows that Sirt2 inhibition reduces HIV-1 and Mtb replication in macrophages and humanized mice, suggesting a dual therapeutic strategy.

DAMP-inducing Peptide Nanofibers and PAMP Combination Adjuvants Boost Functional Lung Tissue-resident Memory CD4+ T Cell Responses

This study shows that combining DAMP-inducing peptide nanofibers with a PAMP enhances lung-resident memory CD4+ T cell responses, improving protection against TB and respiratory diseases.

HIV IMPAIRS AND EXPLOITS PULMONARY TH17 AND TH22 CELL-MEDIATED IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS

This study investigates how HIV affects Th17 and Th22 cell-mediated immunity in the context of Mycobacterium tuberculosis co-infection using a humanized mouse model.

IL-4 and TGF-β Regulate Inflammatory cytokines and Cellular Infiltration in the Lung in Mouse-adapted SARS-CoV-2 Infection

This study investigates how IL-4 and TGF-β regulate inflammation and immune cell infiltration in mouse-adapted SARS-CoV-2 infection, finding that neutralizing these cytokines alters disease pathology.

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication

This study identifies TRIM7 as an E3-ubiquitin ligase that ubiquitinates SARS-CoV-2 M protein to inhibit apoptosis and viral replication.