Author

Mark A. Endsley

The University of Texas Medical Branch at GalvestonORCID 0000-0002-5338-1332Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 3 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Janice Jones EndsleyiD· 4 shared Matthew B. HuanteiD· 3 shared Lucinda Puebla-ClarkiD· 2 shared María González-OrozcoiD· 2 shared Ricardo RajsbaumiD· 2 shared Robin StephensiD· 2 shared Thomas R. SheliteiD· 2 shared Tseng Hsiang-ChiiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Janice Jones EndsleyORCID

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Author profile →

4 papers

Recent·Most cited

Sirtuin2 blockade inhibits replication of Human Immunodeficiency Virus-1 and 1 Mycobacterium tuberculosis in macrophages and humanized mice

Vipul Kumar Singh, Abhishek Mishra, Khanghy Truong, José Alejandro Bohórquez, Suman Sharma, Arshad Khan, Franz Bracher, Kangling L Zhang, Janice Jones Endsley, Mark A. Endsley, Andrew P. Rice, Jason T. Kimata, Guohua Yi, Chinnaswamy Jagannath

This study shows that Sirt2 inhibition reduces HIV-1 and Mtb replication in macrophages and humanized mice, suggesting a dual therapeutic strategy.

Molecular Therapy · Mar 25, 2026Peer-reviewedImmunology

HIV IMPAIRS AND EXPLOITS PULMONARY TH17 AND TH22 CELL-MEDIATED IMMUNE RESPONSES TO MYCOBACTERIUM TUBERCULOSIS

Yazmin B. Martinez-Martinez, Matthew B. Huante, Kubra Fatima Naqvi, Mithil N. Shah, Joshua G. Lisinicchia, Megan A. Files, Jaid Perez, Benjamin B. Gelman, Mark A. Endsley, Janice Jones Endsley

This study investigates how HIV affects Th17 and Th22 cell-mediated immunity in the context of Mycobacterium tuberculosis co-infection using a humanized mouse model.

PLoS Pathogens · Jan 30, 2026Peer-reviewedImmunology

IL-4 and TGF-β Regulate Inflammatory cytokines and Cellular Infiltration in the Lung in Mouse-adapted SARS-CoV-2 Infection

Solomon Taye Sima, Lucinda Puebla-Clark, María González-Orozco, Mark Joseph Endrino, Thomas R. Shelite, Tseng Hsiang-Chi, Yazmin B. Martinez-Martinez, Matthew B. Huante, Hannah G. Federman, Komi Gbédandé, Vineet D. Menachery, Mark C. Siracusa, Mark A. Endsley, Sara M. Dann, Janice Jones Endsley, , Robin Stephens

This study investigates how IL-4 and TGF-β regulate inflammation and immune cell infiltration in mouse-adapted SARS-CoV-2 infection, finding that neutralizing these cytokines alters disease pathology.

bioRxiv · May 13, 2025 · PreprintImmunology

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication

María González-Orozco, Tseng Hsiang-Chi, Adam Hage, Hongjie Xia, Padmanava Behera, Kazi Sabrina Afreen, Yoatzin Peñaflor-Téllez, María I. Giraldo, Matthew B. Huante, Lucinda Puebla-Clark, Sarah van Tol, Abby E. Odle, Matthew R. Crown, Natália Teruel, Thomas R. Shelite, , Ricardo Rajsbaum

This study identifies TRIM7 as an E3-ubiquitin ligase that ubiquitinates SARS-CoV-2 M protein to inhibit apoptosis and viral replication.

Nature Communications · Nov 30, 2024Peer-reviewedMicrobiology