UNC-45A Drives ATP-Independent Microtubule Destabilization via Defect Recognition and Repair Inhibition Contributing to Neurite Dystrophy
Asumi Hoshino, Brian T. Castle, Mihir Shetty, Hannah Khan, Joyce P. Meints, Olga Pletniková, Michael K. Lee, Juan Carlos Troncoso, David J. Odde, Martina Bazzaro
This study identifies UNC-45A as an ATP-independent microtubule severing protein that inhibits repair of defects, leading to microtubule loss and neurite dystrophy in Alzheimer's disease.
bioRxiv · Aug 26, 2025 · PreprintCell Biology