Author

Brian T. Castle

University of MinnesotaORCID 0000-0003-3765-7711Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

David J. OddeiD· 3 shared Asumi HoshinoiD· 2 shared Martina BazzaroiD· 2 shared Mihir ShettyiD· 2 shared Ashley T. HaaseiD· 1 shared Carissa C. DockiD· 1 shared Christopher James TignanelliiD· 1 shared David MasopustiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

David J. OddeORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 26, 2025

UNC-45A Drives ATP-Independent Microtubule Destabilization via Defect Recognition and Repair Inhibition Contributing to Neurite Dystrophy

Asumi Hoshino, Brian T. Castle, Mihir Shetty…·Martina Bazzaro

This study identifies UNC-45A as an ATP-independent microtubule severing protein that inhibits repair of defects, leading to microtubule loss and neurite dystrophy in Alzheimer's disease.

DOI 10.1101/2025.08.26.671351

mousehuman

𝕏 PostBluesky

Cell BiologyJournal of Biological ChemistryPeer-reviewedOct 17, 2023

The Microtubule Severing Protein UNC-45A Counteracts the Microtubule Straightening Effects of Taxol

Asumi Hoshino, Valentino Clemente, Mihir Shetty…·Martina Bazzaro

This paper shows UNC-45A increases microtubule curvature and counteracts Taxol's straightening effects, suggesting a role in drug resistance.

7 citations

experimental assay

𝕏 PostBluesky

Systems BiologybioRxivPreprintMay 22, 2020

Biophysical modeling of the SARS-CoV-2 viral cycle reveals ideal antiviral targets

Brian T. Castle, Carissa C. Dock, Mahya Hemmat…·David J. Odde

The paper uses a biophysical model of the SARS-CoV-2 viral cycle to identify antiviral targets by analyzing parameter sensitivity and pairwise interactions.

17 citations

virusstatistical model

𝕏 PostBluesky