A Novel Phosphatase Reverses the Leloir Pathway to Promote Tagatose Synthesis from Glucose
Aaron M. Love, Christopher G. Toomey, Abhishek Kumar, Sukesh Narayan Kashyap, Dhinesh Kumar Santhamoorthy, Likith Muthuraj, Hannah L. Lynch, Parayil Kumaran Ajikumar, Pravin Kumar R., Nikhil U. Nair, Christine Nicole S. Santos
This paper describes a novel biochemical pathway using a phosphatase to reverse the Leloir pathway in E. coli, enabling direct tagatose synthesis from glucose with high yield.
bioRxiv · Jul 29, 2025 · PreprintBioengineering