Author

Likith Muthuraj

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 1 Approach:experimental assay· 1 Approach:machine learning (classical)· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Nikhil U. NairiD· 2 shared Pravin Kumar R.· 2 shared Aaron M. LoveiD· 1 shared Abhishek KumariD· 1 shared Alexander Kai BuelliD· 1 shared Antonín KunkaiD· 1 shared Anuj ShettyiD· 1 shared Christine Nicole S. SantosiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

Nikhil U. NairORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

An engineered disulfide staple restricts lid loop dynamics and alters substrate specificity of phenylalanine ammonia-lyase

Rebecca Condruti, Likith Muthuraj, Jeevan K. Prakash, Samuel D. Littman, Pravin Kumar R., Nikhil U. Nair

The paper investigates the role of a dynamic loop in AvPAL by engineering disulfide bonds to restrict its mobility, revealing its regulatory function in substrate specificity.

bioRxiv · May 6, 2026 · PreprintBioengineering

A Novel Phosphatase Reverses the Leloir Pathway to Promote Tagatose Synthesis from Glucose

Aaron M. Love, Christopher G. Toomey, Abhishek Kumar, Sukesh Narayan Kashyap, Dhinesh Kumar Santhamoorthy, Likith Muthuraj, Hannah L. Lynch, Parayil Kumaran Ajikumar, Pravin Kumar R., Nikhil U. Nair, Christine Nicole S. Santos

This paper describes a novel biochemical pathway using a phosphatase to reverse the Leloir pathway in E. coli, enabling direct tagatose synthesis from glucose with high yield.

bioRxiv · Jul 29, 2025 · PreprintBioengineering

Mechanism-Guided Engineering of Fluorinase Unlocks EfficientNucleophilic Biofluorination

Michaela Slanska, Daniel C. Volke, Isabel Pardo, Antonín Kunka, Naveen Banchallihundi Krishna, Anuj Shetty, Likith Muthuraj, Gladstone G. Sigamani, Roopa Lalitha, Alexander Kai Buell, Martin Marek, R. Pravin Kumar, Jiřı́ Damborský, Pablo I. Nikel, Zbyněk Prokop

This paper enhances fluorinase catalytic efficiency by engineering mutants and optimizing reaction conditions, achieving a 60-fold increase in turnover rate.

bioRxiv · Jul 28, 2025 · PreprintBiochemistry