Epitranscriptomic Dysregulation Underpins Artemisinin Mechanism of Action
Ameya Sinha, Benjamin Sian Teck Lee, Jumei Samantha Kwah, Jiaqi Liang, Hannah Murray, Radoslaw Igor Omelianczyk, Sebastian Baumgarten, Peter C. Dedon, Peter Rainer Preiser
This study identifies artemisinin's mechanism by showing it disrupts tRNA modifications and biosynthesis in Plasmodium falciparum.
bioRxiv · Aug 28, 2025 · PreprintMicrobiology