This study identifies host adaptation barriers in Plasmodium knowlesi by analyzing multi-omic data from parasites cultured in human and macaque red blood cells.

bioRxiv · Oct 3, 2026 · PreprintMicrobiology

Thermal proteome profiling identifies new drug targets in Plasmodium falciparum parasites

Samuel Pažický, Jerzy Michal Dziekan, Seth Tjia, Selina E. R. Bopp, Dyann F. Wirth, Peter Rainer Preiser, Zbynek Bozdech

The paper identifies new drug targets in Plasmodium falciparum using thermal proteome profiling combined with molecular docking and MS-CETSA.

Molecular & Cellular Proteomics · Oct 1, 2026Peer-reviewedMicrobiology

A chromosome-scale Plasmodium cynomolgi Berok genome reveals a distinct subtelomeric architecture and a highly diverged primate malaria lineage

Adeline C. Y. Chua, Vipin Narang, Eric Jit-Kai Lim, Sourav Nayak, Demi Glidden, Peter Christensen, Vaishnavi Chandramouli, Kanisha Shah, Shu Xuan Tan, Rossarin Suwanarusk, Srinivasan K.G., Arnab Pain, Kevin S. W. Tan, Peter Rainer Preiser, Bruce Russell, , Pablo Juan Bifani

bioRxiv · Aug 21, 2026 · PreprintMicrobiology

Stabilising selection and ecological trade-offs underpin coexistence in a tropical flora

Matti A. Niissalo, Jun Ying Lim, Jia Jun Ngiam, Sitaram Rajaraman, Le Min Choo, Joan Jing Yi Jong, Kang Min Ngo, Felicia Wei Shan Leong, Shawn K. Y. Lum, Henk Beentje, Sven Buerki, Martin W. Callmander, Junhao Chen, M. J. Chua, R.P.J. de Kok, , Jarkko Salojärvi

This study investigates genomic mechanisms of coexistence in a tropical flora, finding stabilising selection and ecological trade-offs between defence and growth.

bioRxiv · Dec 31, 2025 · PreprintGenomics

Epitranscriptomic Dysregulation Underpins Artemisinin Mechanism of Action

Ameya Sinha, Benjamin Sian Teck Lee, Jumei Samantha Kwah, Jiaqi Liang, Hannah Murray, Radoslaw Igor Omelianczyk, Sebastian Baumgarten, Peter C. Dedon, Peter Rainer Preiser

This study identifies artemisinin's mechanism by showing it disrupts tRNA modifications and biosynthesis in Plasmodium falciparum.

bioRxiv · Aug 28, 2025 · PreprintMicrobiology

N6-methyladenosine primes the malaria parasite for transmission

Selina Mussgnug, Tiziano Vignolini, Justine Couble, Patty B. Chen, Dayana C. Farhat, Ameya Sinha, Grégory R G Doré, Délia Dupré, Marion Lambault, Louisa Hadj Abed, Peter Rainer Preiser, Peter C. Dedon, Jessica M. Bryant, Sebastian Baumgarten

This paper identifies N6-methyladenosine (m6A) as a mechanism enabling malaria parasites to rapidly restructure protein synthesis during transmission, dependent on temperature changes and the m6A-binding protein YTH.2.

bioRxiv · Mar 28, 2025 · PreprintMolecular Biology

Cohesin is involved in transcriptional repression of stage-specific genes in the human malaria parasite

Catarina Rosa, Parul Singh, Ameya Sinha, Peter Rainer Preiser, Peter C. Dedon, Sebastian Baumgarten, Artur Scherf, Jessica M. Bryant

The paper investigates the role of cohesin in regulating stage-specific gene expression in Plasmodium falciparum, showing that SMC3 represses genes until their appropriate time of expression.

bioRxiv · Jul 21, 2022 · PreprintMolecular Biology

Transcriptome-wide dynamics of extensive m6A mRNA methylation during Plasmodium falciparum blood-stage development

Sebastian Baumgarten, Jessica M. Bryant, Ameya Sinha, Thibaud Reyser, Peter Rainer Preiser, Peter C. Dedon, Artur Scherf

This study identifies m6A mRNA methylation dynamics in Plasmodium falciparum during blood-stage development, showing its role in regulating gene expression and mRNA stability.

Nature Microbiology · Aug 5, 2019Peer-reviewedMolecular Biology