Sebastian Baumgarten

This study identifies three druggable targets in Plasmodium falciparum gametocytes using high-throughput screening and reveals resistance mechanisms for one compound.

The paper identifies a variant rRNA in Plasmodium falciparum that represses translation during host-to-vector transmission by forming a dominant-negative ribosome.

This study shows that acetyl-CoA synthetase (ACAS) in Plasmodium falciparum is essential for nuclear histone acetylation, which regulates gene expression and the transcriptional cycle during the parasite's life cycle.

This study identifies MaRNAV-1 as an intracellular virus in Plasmodium vivax that increases transmission and alters host immune responses.

The paper investigates m6A methylation in Plasmodium falciparum, showing its role in polyadenylation and transcription termination.

This study identifies artemisinin's mechanism by showing it disrupts tRNA modifications and biosynthesis in Plasmodium falciparum.

This paper identifies N6-methyladenosine (m6A) as a mechanism enabling malaria parasites to rapidly restructure protein synthesis during transmission, dependent on temperature changes and the m6A-binding protein YTH.2.

This study identifies a metabolism-chromatin axis that regulates ribosome heterogeneity in Plasmodium falciparum during host-to-vector transmission.

The paper uses Micro-C to map DNA-DNA contacts in Plasmodium falciparum, revealing heterochromatic and euchromatic structures mediated by MORC/ApiAP2 and other factors.

The paper investigates the role of cohesin in regulating stage-specific gene expression in Plasmodium falciparum, showing that SMC3 represses genes until their appropriate time of expression.

This study identifies m6A mRNA methylation dynamics in Plasmodium falciparum during blood-stage development, showing its role in regulating gene expression and mRNA stability.

This study compares the genomes of two coral species, Stylophora pistillata and Acropora digitifera, revealing significant differences in gene expansion and function related to symbiosis and stress response.