Hierarchical and Spatial Mapping of Whole-Brain c-Fos Activity Reveals Distinct Opioid and Withdrawal Neuronal Ensembles
Kentaro K. Ishii, Yizhe Y. Zhang, Lynn Y. Ren, Alex De Lecea, Suruchi Bakshi, Ariyanna Haygood, Sakura Chujo, Hannah P. Stevenson, Evan Schwartz, Zhe Charles Zhou, Eric R Szelenyi, Sam A. Golden, Daniel Kessler, Garret D. Stuber
The paper maps whole-brain c-Fos activity to identify distinct neuronal ensembles associated with morphine administration and withdrawal, revealing their spatial and molecular characteristics.
bioRxiv · Sep 21, 2025 · PreprintNeuroscience