JAK-STAT pathway activation compromises nephrocyte function in a Drosophila high-fat diet model of chronic kidney disease
Yunpo Zhao, Jianli Duan, Hannah Seah, Joyce van de Leemput, Zhe Han
This study shows that a high-fat diet activates the JAK-STAT pathway in Drosophila nephrocytes, leading to structural and functional disruption, and that inhibiting JAK-STAT reverses this dysfunction.
bioRxiv · Mar 7, 2024Cell Biology