Zhe Han

The paper identifies inflammatory proteolysis of APOL1 in podocytes from HIVAN patients, generating toxic fragments with distinct pathogenic functions.

This study re-analyzes single-cell RNA sequencing data to uncover dynamic cellular processes in hepatocellular carcinoma, including epithelial dedifferentiation and immune cell interactions.

This study identifies DNA damage-driven senescence and ZBP1-cGAS-STING signaling as conserved mechanisms linking cardiovascular-kidney-metabolic comorbidities to HFpEF.

This study identifies cardiac neurons expressing the Akh receptor that mediate high-fat diet-induced arrhythmia in Drosophila.

This paper shows Top2 promotes HPV replication by inducing IL-6 and IL-8 secretion through TLR4, independent of DDR.

This paper introduces a Drosophila model to study HIV-1 Nef and APOL1-G1 interaction, showing they synergistically induce ER stress and nephrocyte cell death.

This study shows that a high-fat diet activates the JAK-STAT pathway in Drosophila nephrocytes, leading to structural and functional disruption, and that inhibiting JAK-STAT reverses this dysfunction.

This study uses a Drosophila model to functionally assess COL4A5 variants for pathogenicity in Alport syndrome, identifying four pathogenic variants and three benign ones.

This study identifies Enc1's association with cognitive function in the hippocampus using systems genetics approaches in BXD mice.

The paper identifies high-resolution eQTLs in kidney tissues using Bayesian fine mapping with integrative priors, improving resolution and functional relevance.

The paper investigates the role of Hsc70-5/mortalin loss in Drosophila Parkinson disease models and shows that autophagy inhibition rescues multiple phenotypes.

The paper identifies a novel recessive frameshift variant in MYL2 causing severe infantile-onset HCM and shows molecular differences between recessive and dominant MYL2 variants.

This paper introduces HATS, a high-throughput system for training head-fixed mice in odor-based cognitive tasks, enabling efficient behavioral assays with minimal human intervention.