Estrogen-Nitric Oxide Signaling Modulates Mitochondrial Dynamics and Endothelial Lipid Handling to Protect Against Early Atherosclerosis
Emmalie R Spry, Hannah Strcula, Giovana Abe Mascoli, Czarina P. Sobejana, Mirabella Zingales, Marta Helena Krieger, Alessandro Gonzalez Salerno, Amarylis Claudine Bonito Azeredo Wanschel
This study shows estrogen and nitric oxide signaling reduce oxLDL uptake and oxidative stress in endothelial cells, modulate mitochondrial dynamics, and decrease inflammation, protecting against early atherosclerosis.
bioRxiv · May 15, 2026 · PreprintPhysiology