Author

Amarylis Claudine Bonito Azeredo Wanschel

High Point UniversityORCID 0000-0002-5603-7983Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Joshua M. HareiD· 3 shared Konstantinos E. HatzistergosiD· 3 shared Alessandro Gonzalez SalernoiD· 2 shared Krystalenia Valasaki· 2 shared Stefan KurtenbachiD· 2 shared Wayne BalkaniD· 2 shared Andrew V. Schally· 1 shared Andrew Victor SchallyiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersDevelopmental Biology

Joshua M. HareORCID

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4 papers

Recent·Most cited

Cardiomyocyte-specific expression of HIF-1α mediates the cardioprotective effects of Growth Hormone-Releasing Hormone (GHRH)

Rosemeire M. Kanashiro‐Takeuchi, Lauro Mitsuru Takeuchi, Wayne Balkan, Karina Dutra Asensi, Raúl A Dulce, Amarylis Claudine Bonito Azeredo Wanschel, Konstantinos E. Hatzistergos, Shathiyah Kulandavelu, Russell Saltzman, Lina A. Shehadeh, Wei Sha, Andrew V. Schally, Stefan Kurtenbach, Joshua M. Hare

This study identifies the HIF-1 pathway as mediating the cardioprotective effects of GHRH-agonists in a murine model of cardiometabolic HFpEF.

American Journal of Physiology-Heart and Circulatory Physiology · Aug 1, 2026Peer-reviewedPhysiology

Estrogen-Nitric Oxide Signaling Modulates Mitochondrial Dynamics and Endothelial Lipid Handling to Protect Against Early Atherosclerosis

Emmalie R Spry, Hannah Strcula, Giovana Abe Mascoli, Czarina P. Sobejana, Mirabella Zingales, Marta Helena Krieger, Alessandro Gonzalez Salerno, Amarylis Claudine Bonito Azeredo Wanschel

This study shows estrogen and nitric oxide signaling reduce oxLDL uptake and oxidative stress in endothelial cells, modulate mitochondrial dynamics, and decrease inflammation, protecting against early atherosclerosis.

bioRxiv · May 15, 2026 · PreprintPhysiology

Oxygen-independent, hormonal control of HIF-1α regulates the developmental and regenerative growth of cardiomyocytes.

Amarylis Claudine Bonito Azeredo Wanschel, Angeliki Daiou, Jeffim N. Kuznetsoff, Stefan Kurtenbach, Katerina Petalidou, Thomai Mouskeftara, Helen Gika, Daniel A. Rodriguez, Eleftherios I. Papadopoulos, Georgios Siokatas, Polyxeni P. Sarri, Kyriaki Karava, Efthimios Tsivoglou, Christine Kottaridi, Alessandro Gonzalez Salerno, , Joshua M. Hare

This paper identifies an O2-independent HIF-1 mechanism regulated by GH/IGF1/SST signaling that controls cardiomyocyte growth through metabolic shifts.

bioRxiv · Jan 31, 2022 · PreprintDevelopmental Biology

Fate of developmental mechanisms of myocardial plasticity in the postnatal heart

Konstantinos E. Hatzistergos, Michael A. Durante, Krystalenia Valasaki, Amarylis Claudine Bonito Azeredo Wanschel, J. William Harbour, Joshua M. Hare

The paper investigates the postnatal fate of developmental gene regulatory networks in the heart, identifying persistent contributions from neural crest-derived cardiomyocytes.

Science Advances · Dec 2, 2020Peer-reviewedDevelopmental Biology