Ergosterol-depleted clinical isolates of Nakaseomyces glabratus can develop multi-drug resistance without apparent fitness and virulence defects
Alexander Maximilian Aldejohann, Nadja Thielemann, Aina Zurita Martinez, Christoph Müller, Tom Gräfenhan, Richard Kriz, Heimo Lagler, Isabell S. Behr, Nathalie Reus, Annika Schöninger, Grit Walther, Lena-Marie Mazan, Hannah Wilhelm, Birgit Willinger, Christina A. Cuomo, , Ronny Martin
The paper identifies ergosterol depletion in Nakaseomyces glabratus as a mechanism for amphotericin B resistance without fitness or virulence defects.
bioRxiv · Aug 28, 2025 · PreprintMicrobiology