Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.
Julio Aguado, Alberto Anastacio Amarilla, Atefeh Taherian Fard, Eduardo A. Albornoz, Alexander Tyshkovskiy, Marius Schwabenland, Harman Kaur Chaggar, Naphak Modhiran, Cecilia Liliana Gomez Inclan, Ibrahim Javed, Alireza A. Baradar, Benjamin Liang, Lianli Peng, Malindrie Dharmaratne, Giovanni Pietrogrande, , Ernst Jurgen Wolvetang
This study shows senolytic drugs reduce brain aging and COVID-19-related neuropathology by targeting senescent cells in human brain organoids and mice.
Nature Aging · Nov 13, 2023Peer-reviewedNeuroscience