The paper generates antigen-specific recombinant bat antibodies from Pteropus alecto to study bat antibody immunity and provides new diagnostic tools.

Frontiers in Immunology · Mar 4, 2026Peer-reviewedImmunology

Vaccine-induced and hybrid immunity against SARS-CoV-2 variants of concern in two cohorts in Queensland, Australia (2021-2022).

Rhys H. Parry, Yingjun Shang, Julian D. J. Sng, Christopher L. D. McMillan, Naphak Modhiran, Alberto Anastacio Amarilla, Ariel Isaacs, Benjamin Liang, David Alexander Muller, Daniel J. Rawle, Andreas Suhrbier, Stevie Anderson, Samuel Kelly, Daniel Watterson, Lucy D. Burr, Alexander A. Khromykh

The paper evaluates vaccine-induced and hybrid immunity against SARS-CoV-2 variants in two cohorts, finding reduced antibody titres and neutralization activity against Omicron variants, with some recovery after multiple vaccinations.

Journal of Medical Virology · Oct 1, 2025Peer-reviewedMicrobiology

A protective bispecific antibody targets both Nipah virus surface glycoproteins and limits viral escape

Ariel Isaacs, Guillermo Valenzuela, Xinghai Zhang, Naphak Modhiran, Jennifer A. Barr, Nazia Thakur, Yu Shang Low, Rhys H. Parry, James B. Barnes, Ronald Jara, Johanna Himelreichs, Yanfeng Yao, Camila Deride, Barbara Barthou-Gatica, Constanza Salinas-Rebolledo, , Daniel Watterson

This paper develops a bispecific antibody that targets both Nipah virus surface glycoproteins, reducing viral escape and enhancing protection against NiV disease.

bioRxiv · Mar 11, 2025 · PreprintMicrobiology

Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology.

Julio Aguado, Alberto Anastacio Amarilla, Atefeh Taherian Fard, Eduardo A. Albornoz, Alexander Tyshkovskiy, Marius Schwabenland, Harman Kaur Chaggar, Naphak Modhiran, Cecilia Liliana Gomez Inclan, Ibrahim Javed, Alireza A. Baradar, Benjamin Liang, Lianli Peng, Malindrie Dharmaratne, Giovanni Pietrogrande, , Ernst Jurgen Wolvetang

This study shows senolytic drugs reduce brain aging and COVID-19-related neuropathology by targeting senescent cells in human brain organoids and mice.

Nature Aging · Nov 13, 2023Peer-reviewedNeuroscience

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike-ACE2 receptor interaction

Eduardo A. Albornoz, Alberto Anastacio Amarilla, Naphak Modhiran, Sandra E. Parker, Xaria X. Li, Danushka K. Wijesundara, Adriana C. Pliego Zamora, Christopher L. D. McMillan, Benjamin Liang, Nias Y. G. Peng, Julian D. J. Sng, Fatema Tuj Saima, Devina Paramitha, Rhys H. Parry, Michael Selorm Avumegah, , Trent M. Woodruff

This study shows SARS-CoV-2 activates microglial NLRP3 inflammasome via spike-ACE2 interaction, potentially linking viral infection to neurological symptoms like Parkinson's.

bioRxiv · Jan 11, 2022 · PreprintNeuroscience