Vulnerability of invasive glioma cells to lysosomal membrane instabilization
Vadim Le Joncour, Maija Hyvönen, Pauliina Filppu, Pauliina S. Turunen, Harri Sihto, Isabel Burghardt, Heikki Joensuu, Olli Tynninen, Juha Jääskeläinen, Michael Weller, Kaisa Lehti, Pirjo Laakkonen
This paper identifies MDGI as a biomarker for invasive glioma and shows that targeting lysosomal membrane permeabilization with clemastine reduces tumor viability and prolongs survival in preclinical models.
bioRxiv · Mar 5, 2018 · PreprintCancer Biology