Author

Pirjo Maarit Laakkonen

University of HelsinkiORCID 0000-0002-9620-095XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Hanna E. SeppäneniD· 1 shared Harri K. MustoneniD· 1 shared Harri Sihto· 1 shared Heikki Joensuu· 1 shared Isabel Burghardt· 1 shared Juha Jääskeläinen· 1 shared Kaisa Lehti· 1 shared Maija Hyvönen· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Hanna E. SeppänenORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 4, 2025

Therapeutic Eradication of Cancer-associated Fibroblasts Inhibits in vivo progression of Pancreatic Cancer

Matilda Roos-Mattila, Harri K. Mustonen, Markus J. V. Vähä-Koskela…·Hanna E. Seppänen

This study shows that clemastine eradicates cancer-associated fibroblasts, halts pancreatic cancer progression, and synergizes with gemcitabine to inhibit metastasis.

DOI 10.1101/2025.11.04.686484

mouseorganoid / primary culture

𝕏 PostBluesky

Cancer BiologybioRxivPreprintMar 5, 2018

Vulnerability of invasive glioma cells to lysosomal membrane instabilization

Vadim Le Joncour, Maija Hyvönen, Pauliina Filppu…·Pirjo Laakkonen

This paper identifies MDGI as a biomarker for invasive glioma and shows that targeting lysosomal membrane permeabilization with clemastine reduces tumor viability and prolongs survival in preclinical models.

DOI 10.1101/276402

humanbulk RNA-seq

𝕏 PostBluesky