A Machine Learning- 3D Microvessel Platform Identifies Kinase Targets Restoring Blood-Brain-Barrier Endothelial Integrity.
Yu Jung Shin, Ling Wei, Sumin Hong, Christina Ren, M. Zigman Jeffrey, Jessica Cardenas, Harry Higgins, Nhi Ho, Kira M. Evitts, Joseph D. Smith, Jing‐fei Dong, Alexis Kaushansky, Ying Yi Zheng
This paper develops a 3D human brain endothelial platform combined with machine learning to identify kinase inhibitors that restore blood-brain barrier integrity in TBI.
bioRxiv · Dec 15, 2025 · PreprintBioengineering