Author

Harshita Sharma

RIKEN Center for Integrative Medical Sciences

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Hazuki TakahashiiD· 2 shared Matthew N. Z. ValentineiD· 2 shared Naoko TokiiD· 2 shared Piero CarninciiD· 2 shared Stefano GustincichiD· 2 shared Abdul RahmaniD· 1 shared Debojyoti ChakrabortyiD· 1 shared Hiromi Nishiyori Sueki· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMolecular Biology

Hazuki TakahashiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

MLC1 alteration in iPSCs give rise to disease-like cellular vacuolation phenotype in the astrocyte lineage

Saumya Sharma, Vishal Bharti, Prosad Kumar Das, Abdul Rahman, Harshita Sharma, Riya Rauthan, Madhumita RC, Neerja Gupta, Rashmi Shukla, Sujata Mohanty, Madhulika Kabra, Kevin R. Francis, Debojyoti Chakraborty

This study generates iPSC models of MLC by reprogramming patient-derived cells and gene editing, revealing disease-specific vacuolation in astrocytes and differentially expressed genes related to neurological disorders.

Orphanet Journal of Rare Diseases · Mar 26, 2026Peer-reviewedCell Biology

Decryption of sequence, structure, and functional features of SINE repeat elements in SINEUP non-coding RNA-mediated post-transcriptional gene regulation

Harshita Sharma, Matthew N. Z. Valentine, Naoko Toki, Hiromi Nishiyori Sueki, Stefano Gustincich, Hazuki Takahashi, Piero Carninci

The paper investigates sequence, structure, and functional features of SINE-derived RNAs in SINEUP non-coding RNAs, showing their role in post-transcriptional gene regulation through interactions with RBPs and ribosomal RNAs.

Nature Communications · Feb 21, 2024Peer-reviewedMolecular Biology

SINEUP long non-coding RNA acts via PTBP1 and HNRNPK to promote translational initiation assemblies

Naoko Toki, Hazuki Takahashi, Harshita Sharma, Matthew N. Z. Valentine, Mohammed Ferdous‐Ur Rahman, Silvia Zucchelli, Stefano Gustincich, Piero Carninci

The paper investigates how SINEUP lncRNAs enhance translation by interacting with PTBP1 and HNRNPK to facilitate translational initiation complexes in HEK293T/17 cells.

Nucleic Acids Research · Sep 23, 2020Peer-reviewedMolecular Biology