An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning
Anastasios Balaskas, Isabelle Kraus, Hatice O. Ozguldez, Persia Akbari Omgba, René Buschow, Adriano Bolondi, Idan Berlad, Jacob H. Hanna, Helene Kretzmer, Aydan Bulut-Karslıoğlu
This paper develops a hypoxia-mediated mouse embryo model to study neural patterning and shows hypoxia enhances anterior neural cell identity through HIF1a and TGFβ modulation.
bioRxiv · Jun 17, 2025 · PreprintDevelopmental Biology