Adriano Bolondi

Inferring cell differentiation maps from lineage tracing data

The paper introduces Carta, an algorithm that infers cell differentiation maps from single-cell lineage tracing data, showing improved accuracy over existing methods in simulated and real data.

An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning

This paper develops a hypoxia-mediated mouse embryo model to study neural patterning and shows hypoxia enhances anterior neural cell identity through HIF1a and TGFβ modulation.

Integrated Molecular-Phenotypic Profiling Reveals Metabolic Control of Morphological Variation in Stembryos

The paper identifies early metabolic imbalances as drivers of phenotypic variation in stembryos and shows how metabolic interventions can correct aberrant morphology and lineage bias.

Discovery and characterization of LNCSOX17 as an essential regulator in human endoderm formation

The paper identifies and characterizes LNCSOX17, a lncRNA essential for human endoderm formation, showing its role in regulating transcriptome and differentiation.

In vivo dissection of a clustered-CTCF domain boundary reveals developmental principles of regulatory insulation

The paper investigates how clustered-CTCF boundaries function in vivo, showing that individual CTCF sites can override other factors and that insulation strength modulates gene expression and phenotypes.

Emergence and patterning dynamics of mouse definitive endoderm

This study investigates the emergence and patterning dynamics of mouse definitive endoderm using in vivo and in vitro models, revealing self-sorting and Sox17 expression patterns.

Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites

The paper describes a method to generate trunk-like structures from mouse embryonic stem cells that mimic embryonic development features.