Jacob H. Hanna

The paper shows that midgestational metabolic constraints in purine metabolism drive distinct strategies for placenta and fetal growth in mice and humans.

This paper uses ex utero culture to study mouse embryogenesis from gastrulation to fetal development, revealing metabolically independent programs and environmental influences on metabolic transitions.

The paper introduces a differential model m6ADyn to predict m6A dynamics by integrating mRNA metabolism and validates its predictions through experimental confirmation.

This paper develops a hypoxia-mediated mouse embryo model to study neural patterning and shows hypoxia enhances anterior neural cell identity through HIF1a and TGFβ modulation.

This paper develops a transgene-free human post-implantation embryo model from genetically unmodified naive PSCs, recapitulating key developmental stages and extra-embryonic tissues.

The paper shows that primed human pluripotent stem cells can be converted into trophoblast stem cells by inhibiting the TGFβ pathway, producing TSCs indistinguishable from those derived from placenta or naive PSCs.

This study uses brain organoids to model WOREE, a severe epileptic encephalopathy, identifying CNS abnormalities and showing potential therapeutic rescue via WWOX expression.

This study identifies signaling pathways that enable the expansion of human naive pluripotent stem cells in defined conditions and highlights differences between mouse and human naive pluripotency.

This study uses APEX proximity-proteomics to analyze the spatio-temporal proteomic changes during stress granule disassembly, identifying novel proteins and revealing SUMOylation's role in ALS pathogenesis.

The paper investigates functional compensation among Ythdf m6A readers in mouse gametogenesis and embryonic stem cells, revealing dosage-dependent redundancy and distinct roles.

This paper introduces MASTER-seq, a method to quantitatively profile m6A sites at single-nucleotide resolution, revealing a predictable code that determines m6A stoichiometry and dynamics.

This study identifies the Gatad2a-Chd4-Mbd3 subcomplex of the NuRD complex as a key inhibitor of naive pluripotency, showing that its disruption enables deterministic reprogramming of somatic cells to iPSCs.

This paper investigates how m6A RNA methylation in the brain is regulated by stress and shows its role in fear memory, transcriptome response, and synaptic plasticity, with implications for stress-related disorders.

The paper shows OCT4 prevents cell fate change by blocking MITF's effects in embryonic stem cells and other differentiated cells.

This paper maps high-resolution epigenetic and biosynthetic changes during reprogramming of fibroblasts to iPSCs, identifying two gene modules regulated by different mechanisms.

This paper reviews recent advances in understanding the molecular mechanisms and signaling pathways that regulate pluripotent stem cell states in vitro and their reprogramming in somatic cells across species.