Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations
Jeannette L. Tenthorey, Serena del Banco, Ishrak Ramzan, Hayley Klingenberg, Chang Liu, Michael Emerman, Harmit Singh Malik
The paper shows that indels, not just missense mutations, enable antiviral proteins like TRIM5 to evolve new functions against viruses.
Cell Genomics · Mar 26, 2025Peer-reviewedEvolutionary Biology