Jeannette L. Tenthorey

Heterozygous and generalist MxA super-restrictors overcome breadth-specificity tradeoffs in antiviral restriction

The paper identifies strategies for MxA to overcome breadth-specificity tradeoffs in antiviral restriction by using heterozygous and generalist super-restrictor variants.

Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations

The paper shows that indels, not just missense mutations, enable antiviral proteins like TRIM5 to evolve new functions against viruses.

Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes

The paper traces the evolutionary origins of Mx proteins, showing they predate the interferon system and are widespread across eukaryotes, including fungi, plants, and early-branching lineages.

An all-atom view into the disordered interaction interface of the TRIM5α PRYSPRY domain and the HIV capsid

This paper uses molecular dynamics simulations to analyze the TRIM5α PRYSPRY domain interaction with HIV capsid, revealing structural differences between human and rhesus TRIM5 that explain HIV restriction efficiency.