Mitochondrial NAD+ import gates neuronal resilience to active SARM1
Lilianne Barbar, Anushka Bhat, Si Jia Chen, Amy M. Strickland, Sarah Schurr, Shea Sundali, Hayoung Kim, Yo Sasaki, A Joseph Bloom, Jeffrey Milbrandt, Aaron DiAntonio
This study shows that enhancing mitochondrial NAD+ import through SLC25A51 protects neurons from SARM1-driven degeneration by preventing coupled metabolic failure.
bioRxiv · Oct 11, 2026 · PreprintNeuroscience