Structural basis for allosteric regulation of human phosphofructokinase-1
Eric M. Lynch, Heather Hansen, Lauren Salay, Madison Cooper, Stepan Timr, Justin M. Kollman, Bradley A. Webb
This study determines the cryoEM structures of human PFK1 in R- and T-states, revealing eukaryotic allosteric regulation mechanisms and the role of the C-terminus in autoinhibition.
bioRxiv · Mar 15, 2024Biochemistry