Author

Bradley A. Webb

West Virginia UniversityORCID 0000-0002-5299-2852Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Eric M. LynchiD· 2 shared Justin M. KollmaniD· 2 shared Ku‐Lung HsuiD· 2 shared Lauren E. SalayiD· 2 shared Shuangyu LuoiD· 2 shared Xiaoding JiangiD· 2 shared Yi‐Chih LiniD· 2 shared 5· 1 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

Eric M. LynchORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Covalent PFKL Activator Suppresses Tumor Growth

Xiaoding Jiang, Eric M. Lynch, Congcong Lyu, Crystal N. Wilson, Lauren E. Salay, Hayden T. Hess, Scott N. Lyons, Shuangyu Luo, Gibae Kim, Hsin‐Ru Chan, 5, Lauren G. Zacharias, Thomas P. Mathews, Yi‐Chih Lin, Bradley A. Webb, , Ku‐Lung Hsu

This paper develops a covalent PFKL activator that disrupts cancer cell metabolism and delivers a cytotoxic payload, showing efficacy in vitro and in vivo.

Nature Chemical Biology · Aug 5, 2026Peer-reviewedBiochemistry

High-Speed AFM Reveals Ligand-Dependent Supramolecular Switching of Human Phosphofructokinase-1

Yi‐Chih Lin, Shuangyu Luo, Arnav Patil, Nicholas Primanis-Erickson, Xiaoding Jiang, Bradley A. Webb, Ku‐Lung Hsu

This study uses HS-AFM and simulations to show ligand-dependent assembly switching of human PFKL, revealing structural changes in response to ATP and F6P.

bioRxiv · May 12, 2026 · PreprintBiophysics

F26BP enables control of glycolysis rate independent of energy state

Megan M. Kober, Xinyi Yang, Bradley A. Webb, Denis V. Titov

The paper shows F26BP regulates glycolytic rate independently of energy state, distinguishing it from other regulators, and identifies downstream intermediates that control F26BP levels.

bioRxiv · Jan 31, 2026 · PreprintBiochemistry

Structural basis for allosteric regulation of human phosphofructokinase-1

Eric M. Lynch, Heather Hansen, Lauren Salay, Madison Cooper, Stepan Timr, Justin M. Kollman, Bradley A. Webb

This study determines the cryoEM structures of human PFK1 in R- and T-states, revealing eukaryotic allosteric regulation mechanisms and the role of the C-terminus in autoinhibition.

bioRxiv · Mar 15, 2024Biochemistry