Heather M. Murdoch

Combined lactate- and phosphate-dependent cytoplasmic acidification drives Mycobacterium tuberculosis growth arrest at acidic pH

This paper identifies that lactate and phosphate together cause cytoplasmic acidification and reduced proton motive force, leading to growth arrest in Mycobacterium tuberculosis at acidic pH.

Mycobacterium tuberculosis growth arrest on propionate at acidic pH is suppressed by mutations in phoPR and pyrazinamide treatment

This study identifies mutations in phoPR and pyrazinamide treatment as factors suppressing Mtb growth arrest on propionate at acidic pH.