Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse model
André Heinen, André Spychala, Lucas Ballmann, Stefanie Gödecke, Zewa Faradj, Katharina Bottermann, Heba Zabri, Jens W. Fischer, Patrick Petzsch, Axel Gödecke
This paper develops a mouse model of diabetes-induced heart failure with preserved ejection fraction (HFpEF) by combining high-fat, high-sucrose diet and streptozotocin, showing distinct metabolic and cardiac changes compared to other HFpEF models.
bioRxiv · Oct 23, 2025 · PreprintPhysiology