Patrick Petzsch

MIC13-linked cristae disruption causes metabolic failure and early fibrotic remodelling in mitochondrial liver disease

This study uses patient-derived iPSCs to model a MIC13 variant causing mitochondrial liver disease, revealing metabolic defects and early fibrosis through multi-omics analysis.

Permissive and instructive Hox codes govern limb positioning

This study identifies Hox4/5 and Hox6/7 genes' roles in forelimb positioning through loss- and gain-of-function experiments in chick embryos, showing Hox4/5 provide permissive cues and Hox6/7 determine limb position.

Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse model

This paper develops a mouse model of diabetes-induced heart failure with preserved ejection fraction (HFpEF) by combining high-fat, high-sucrose diet and streptozotocin, showing distinct metabolic and cardiac changes compared to other HFpEF models.

The transcription factor reservoir and chromatin landscape in activated plasmacytoid dendritic cells

This study characterizes the transcription factor reservoir and chromatin landscape in naive and TLR9-activated plasmacytoid dendritic cells across multiple timepoints.