Author

André Spychala

Düsseldorf University HospitalORCID 0000-0002-5731-9923Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:long-read sequencing· 1 Approach:statistical model· 1

Frequent Co-Authors

Axel GödeckeiD· 2 shared Alexander LangiD· 1 shared André HeineniD· 1 shared Daniel OehleriD· 1 shared Heba Zabri· 1 shared Jens W. FischeriD· 1 shared Jorge Lira RuasiD· 1 shared Julia SzendroediiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersPhysiology

Axel GödeckeORCID

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2 papers

Recent·Most cited

PhysiologybioRxivPreprintOct 23, 2025

Obesity and diabetes related disturbances in systemic metabolism induce a cardiometabolic heart failure with preserved ejection fraction phenotype in a combined high-fat, high sucrose diet and streptozotocin mouse model

André Heinen, André Spychala, Lucas Ballmann…·Axel Gödecke

This paper develops a mouse model of diabetes-induced heart failure with preserved ejection fraction (HFpEF) by combining high-fat, high-sucrose diet and streptozotocin, showing distinct metabolic and cardiac changes compared to other HFpEF models.

DOI 10.1101/2025.10.23.684124

mousebulk RNA-seq

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GeneticsBMC BiologyPeer-reviewedJul 30, 2022

Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity

Daniel Oehler, André Spychala, Axel Gödecke…·Ralf Westenfeld

The paper uses long-read mRNA sequencing to analyze PGC-1α transcripts in murine and human hearts, identifying novel isoforms and promoters regulated in ischemia and obesity.

21 citations

mousehuman

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