Jens W. Fischer

This study shows that Alzheimer's transgenic mice experience reduced left ventricular function after myocardial ischemia and reperfusion, linked to elevated IL-1 beta, altered platelet activation, and cardiac remodeling.

This paper develops a mouse model of diabetes-induced heart failure with preserved ejection fraction (HFpEF) by combining high-fat, high-sucrose diet and streptozotocin, showing distinct metabolic and cardiac changes compared to other HFpEF models.

This study shows that platelets induce cardiac cell apoptosis via FasL after acute myocardial infarction, contributing to cardiac damage and dysfunction.