Skeletal Metastasis of Prostate Cancer Is Augmented by Activation of EphA2 Noncanonical Signaling and Ligand-Deficient Bone Microenvironment
Ryan Lingerak, Aaron P. Petty, Xiaojun Shi, Soyeon Kim, Hebei Lin, Jer‐Tsong Hsieh, Dean G. Tang, Bangyan L. Stiles, David N. Wald, Sooryanarayana Varambally, Arul M. Chinnaiyan, Zhenghong Lee, Colm M. Morrissey, Bingcheng Wang
This study shows EphA2 overexpression and loss of its ligands in prostate cancer promote bone metastasis through noncanonical signaling in a ligand-deficient bone microenvironment.
bioRxiv · Sep 25, 2024 · PreprintCancer Biology