Intermediately Methylated Regions in Normal Cells Are Epimutation Hotspots in Cancer
Mohamed Mahgoub, Haley Abel, Nidhi Davarapalli, Heidi Struthers, Emilee N. Kotnik, Brittany Johnson, Christopher Markovic, Catrina C. Fronick, Robert S. Fulton, Michael P. Meers, David H. Spencer
The paper identifies intermediate methylation regions in normal cells as epimutation hotspots in cancer, showing they are prone to clonal epimutations in leukemia and other cancers.
bioRxiv · Sep 18, 2025 · PreprintGenomics