Author

Emilee N. Kotnik

University of MichiganORCID 0000-0002-9229-3378Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Audrey C. A. CleureniD· 2 shared David GinsburgiD· 2 shared David R. Siemieniak· 2 shared Guojing Zhu· 2 shared Kärt TombergiD· 2 shared Randal Joseph WestrickiD· 2 shared Thomas L. SaundersiD· 2 shared Alexander J. JohnstoniD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenetics

Audrey C. A. CleurenORCID

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3 papers

Recent·Most cited

Intermediately Methylated Regions in Normal Cells Are Epimutation Hotspots in Cancer

Mohamed Mahgoub, Haley Abel, Nidhi Davarapalli, Heidi Struthers, Emilee N. Kotnik, Brittany Johnson, Christopher Markovic, Catrina C. Fronick, Robert S. Fulton, Michael P. Meers, David H. Spencer

The paper identifies intermediate methylation regions in normal cells as epimutation hotspots in cancer, showing they are prone to clonal epimutations in leukemia and other cancers.

bioRxiv · Sep 18, 2025 · PreprintGenomics

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse

Kärt Tomberg, Randal Joseph Westrick, Emilee N. Kotnik, David R. Siemieniak, Guojing Zhu, Thomas L. Saunders, Audrey C. A. Cleuren, David Ginsburg

The paper identifies a de novo mutation in Plcb4 that suppresses thrombosis in mice with Factor V Leiden and tissue factor pathway inhibitor mutations.

PLoS Genetics · Sep 6, 2018Peer-reviewedGenetics

A sensitized mutagenesis screen in Factor V Leiden mice identifies novel thrombosis suppressor loci

Randal Joseph Westrick, Kärt Tomberg, Amy E. Siebert, Guojing Zhu, Mary E. Winn, Sarah L. Dobies, Sara L. Manning, Marisa A Brake, Audrey C. A. Cleuren, Linzi M Hobbs, Lena M. Mishack, Alexander J. Johnston, Emilee N. Kotnik, David R. Siemieniak, Jishu Xu, , David Ginsburg

The paper identifies novel thrombosis suppressor loci using a sensitized mutagenesis screen in Factor V Leiden mice, finding F8 and the Tfpi/F3 axis, as well as Actr2, play key roles in thrombosis regulation.

Proceedings of the National Academy of Sciences · Aug 21, 2017Peer-reviewedGenetics