Development of a Notch pathway assay and quantification of functional Notch pathway activity in T-cell acute lymphoblastic leukemia
Kirsten Cante-Barrett, Laurent Holtzer, Henk van Ooijen, Rico Hagelaar, Valentina Cordo, Wim Verhaegh, Anja van de Stolpe, Jules P.P. Meijerink
The paper develops a Notch pathway activity assay using mRNA levels of direct NOTCH target genes and shows that high activity correlates with better event-free survival in T-cell acute lymphoblastic leukemia patients.
Cancers · Oct 27, 2020Peer-reviewedCancer Biology