μ-Opioid Receptor Superagonists Engage Sodium-Bound Receptor States
Alexander Powell, Nicholas W. Griggs, Jorge A. Iñiguez-Lluhı́, Henry Mosberg, John R. Traynor
This paper investigates how superagonists at the μ-opioid receptor are less sensitive to Na+ ions compared to standard agonists, suggesting a conformational induction mechanism.
bioRxiv · Jan 12, 2026 · PreprintPharmacology & Toxicology