Pharmacology & ToxicologybioRxivPreprint
μ-Opioid Receptor Superagonists Engage Sodium-Bound Receptor States
Alexander Powell, Nicholas W. Griggs, Jorge A. Iñiguez-Lluhı́…·John R. Traynor
This paper investigates how superagonists at the μ-opioid receptor are less sensitive to Na+ ions compared to standard agonists, suggesting a conformational induction mechanism.
DOI 10.64898/2025.12.01.691612