John R. Traynor

PN6047 Demonstrates Broad Preclinical Efficacy in Headache Models as a Novel Delta-Opioid Receptor Agonist

This paper evaluates the efficacy of PN6047, a novel DOR agonist, in preclinical headache models and finds it effectively reduces pain and prevents medication overuse headache.

Effects of the Mu Opioid Receptor Positive Allosteric Modulator BMS-986122 On Opioid Efficacy in Rat Neuropathic Pain States

This study shows that BMS-986122 enhances low-dose opioid efficacy in rat neuropathic pain models without increasing adverse effects.

Discovery and dynamic pharmacology of μ-opioid receptor positive allosteric modulators

This study discovers μ-opioid receptor positive allosteric modulators (PAMs) and investigates their dynamic mechanism of action to enhance opioid agonist activity while reducing side effects.

μ-Opioid Receptor Superagonists Engage Sodium-Bound Receptor States

This paper investigates how superagonists at the μ-opioid receptor are less sensitive to Na+ ions compared to standard agonists, suggesting a conformational induction mechanism.

Delta Opioid Receptors on Parvalbumin Neurons are Necessary for the Convulsant and Anxiolytic Effects of the Delta Agonist SNC80

This study shows that DOR on PV interneurons are necessary for the convulsant and anxiolytic effects of SNC80, but not for locomotor or respiratory responses.

The effects of chronic neuropathic pain states on the discriminative stimulus effect of fentanyl and other MOR agonists

This study examines how chronic neuropathic pain affects the discriminative stimulus effects of opioids and cocaine, finding no significant changes in opioid responses but increased dopaminergic generalization.

The effects of chronic neuropathic pain on the self-administration of highly potent MOR agonist, fentanyl

This study examines how chronic neuropathic pain affects self-administration of fentanyl and cocaine, finding no significant change in fentanyl intake but increased intake of a specific dose over time.

Xylazine Exacerbates Fentanyl-Induced Respiratory Depression and Bradycardia

This study shows that xylazine worsens fentanyl-induced respiratory depression and bradycardia in mice, increasing overdose risk.