Multi-compartment immune and tumor cell reprogramming by IFNa2 overcomes colon cancer immunotherapy resistance
Zainab A. Tiamiyu, Patrick Czabala, Jennifer Worthy, Luis Velasquez Zarate, Mei Zheng, Dakota B. Poschel, Kendra Fick, Dafeng Yang, Henry R Monnig, Richa Rashmi, Sergei Bombin, Priscilla S. Redd, Kebin Liu
This paper shows that delivering IFN2 via LNPs reprograms tumor and immune cells in ICI-resistant CRC, enhancing PD-1 blockade efficacy and reducing metastasis.
bioRxiv · Aug 28, 2026 · PreprintImmunology