Sergei Bombin

Multi-gene biomarkers reveal spatial organization and subpopulation-specific damage response in intrahepatic biliary epithelial cells

The paper identifies BEC subpopulations and their spatial organization using scRNA-seq and metagenes, revealing subpopulation-specific damage responses in mouse liver.

Multi-compartment immune and tumor cell reprogramming by IFNa2 overcomes colon cancer immunotherapy resistance

This paper shows that delivering IFN2 via LNPs reprograms tumor and immune cells in ICI-resistant CRC, enhancing PD-1 blockade efficacy and reducing metastasis.

B cell-intrinsic IRF8 transcriptionally reprograms antigen presentation to sustain CD8⁺ T cell antitumor immunity

This study identifies IRF8 as a B cell-intrinsic regulator of antigen presentation that sustains CD8⁺ T cell antitumor immunity and predicts response to PD-1 blockade therapy.

Quantitative 3D imaging of mouse and human intrahepatic bile ducts in homeostasis and liver injury

This paper develops a 3D imaging and analysis pipeline for intrahepatic bile ducts in mouse and human tissues, revealing structural changes in health and disease.

Tet1 safeguards lineage allocation in intestinal stem cells

This study shows Tet1 buffers intestinal stem cell differentiation by reducing sensitivity to extrinsic signals, without altering chromatin accessibility.

Sox9 links biliary maturation to branching morphogenesis

This study shows that Sox9 is essential for the development of small bile ductules during intrahepatic bile duct morphogenesis, with loss of Sox9 leading to impaired branching and BEC maturation.