Decreased endothelial cell retinoic acid signaling accelerates progression of single ventricle pulmonary arteriovenous malformations
Henry Rousseau, Tina C. Wan, Nhi Nguyen, Jaime Wendt Andrae, Michael Tschannen, Angela Mathison, Victor X. Jin, Olivia Groh, Xingyan Zhou, Stryder M. Meadows, Ramani Ramchandran, Igor O Shmarakov, Amy Pan, Andrew D. Spearman
This study uses scRNA-seq to identify decreased retinoic acid signaling in endothelial cells post-Glenn surgery, linking it to accelerated PAVM progression and suggesting dietary vitamin A modification as a potential therapeutic strategy.
bioRxiv · Dec 21, 2025 · PreprintPhysiology