Xingyan Zhou

This study uses scRNA-seq to identify decreased retinoic acid signaling in endothelial cells post-Glenn surgery, linking it to accelerated PAVM progression and suggesting dietary vitamin A modification as a potential therapeutic strategy.

The paper uses single cell RNA sequencing to assess the effects of protein-altering variants in three genes, showing that single cell expression signatures are more effective than bulk assays and computational models for predicting pathogenicity.