Andrew D. Spearman

This study uses scRNA-seq to identify decreased retinoic acid signaling in endothelial cells post-Glenn surgery, linking it to accelerated PAVM progression and suggesting dietary vitamin A modification as a potential therapeutic strategy.

The paper investigates how loss of pulsatile flow affects pulmonary vascular structure in SV-CHD patients and identifies PDGFB as a key mediator of vascular remodeling.

This study develops a rat model of unilateral Glenn circulation to study early and progressive intrapulmonary shunting in single ventricle pulmonary arteriovenous malformations.