Transient Early Postnatal Neuronal Hyperexcitation Results in Lasting Social Preference Deficits
Haleigh Bach, Mikael Nakamura-Vernet, Kevin Lançon, Pierre Drapeau, Hidaya Ben Mhenni, Cameron Oram, Sarah Martin, Philippe Séguéla, Jean-Francois Poulin
This study shows that inducing hyperexcitation in neonatal mice leads to long-term social behavior deficits and increased interneuron density, linking E/I imbalance to ASD-like symptoms.
bioRxiv · Sep 4, 2025 · PreprintNeuroscience