Three-dimensional single-particle reconstruction by atomic force microscopy allows rapid structural-based validation of recombinant SARS-CoV-2 Spike protein from a single topology image
Liisa Lutter, David M. Beal, Maria Stanley, Joanne Roobol, Sarah Martin, James D. Budge, Phoebe E. Lee, Emi Nemoto‐Smith, Ian R. Brown, Martin J. Warren, Christopher Mark Smales, Wei‐Feng Xue
This paper develops a method to perform three-dimensional single-particle reconstruction using AFM for rapid structural validation of proteins, demonstrated on SARS-CoV-2 Spike protein.
Nanoscale Horizons · Jan 1, 2026Peer-reviewedBiophysics