GeneticsPLoS ONEPeer-reviewed
Characterization of a C9orf72 Knockout Danio rerio model for ALS and cross-species validation of potential therapeutics screened in Caenorhabditis elegans.
Alexandre Emond, Carl Laflamme, Martine Therrien…·J. Alex Parker
The paper develops a zebrafish C9orf72 knockout model for ALS, identifies pizotifen malate as a potential therapeutic, and validates its efficacy in both zebrafish and C. elegans models.
DOI 10.1371/journal.pone.0346613